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Addyi (flibanserin): Female Libido Drug Side Effects & Interactions

What is flibanserin? What is flibanserin used for?

Addyi (flibanserin) is an oral drug used for treating low sexual desire in women. The mechanism of action of flibanserin is not completely understood. Flibanserin affects the way the brain works by interfering with communication among the brain’s nerves in areas of the brain that control sexual desire and other pleasurable sensations. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on nerves. The attachment of neurotransmitters either stimulates or inhibits the function of the nearby nerves. Flibanserin blocks several of the receptors on nerves including dopamine type 4, and serotonin type 2A, 2B and 2C receptors. It also stimulates serotonin type 1A. How these effects improve sexual desire in women is unknown. Scientists think that flibanserin may regulate areas of the brain that control sexual desire in premenopausal women with reduced sexual interest and desire. The FDA approved flibanserin on August 18, 2015.

What brand names are available for flibanserin?

Addyi

Is flibanserin available as a generic drug?

No

Do I need a prescription for flibanserin?

Yes

What are the side effects of flibanserin?

WARNING

Flibanserin may cause low blood pressure and
fainting. Patients should lie down and seek medical help if they experience
fainting.

Flibanserin causes drowsiness and reduces
alertness. Patients should avoid operating machinery, driving, or performing
other dangerous activities for at least 6 hours after taking each dose of
flibanserin.

What is the dosage for flibanserin?

Flibanserin is administered once daily by mouth at bedtime. It should
be stopped after 8 weeks if there is no improvement in symptoms.

Which drugs or supplements interact with flibanserin?

Flibanserin can cause low blood pressure and fainting. Therefore, flibanserin
should not be combined with alcohol and other drugs that also cause low blood
pressure.

Flibanserin is metabolized or broken down by liver enzymes. Drugs that induce
the activity of these enzymes will decrease blood levels of flibanserin. Examples
of such drugs include

Flibanserin should not be combined
with drugs that decrease its blood levels.

Drugs that block the action of enzymes that breakdown flibanserin will
increase blood levels and side effects of flibanserin. Therefore, flibanserin
should not be combined with

Flibanserin increases blood levels of
digoxin
(Lanoxin). This may lead to digoxin
toxicity.



QUESTION

If menopause occurs in a woman younger than ___ years, it is considered to be premature.
See Answer

Is flibanserin safe to take if I’m pregnant or breastfeeding?

Flibanserin has not been adequately studied in pregnant women.

Flibanserin has not been studied in women who are
breastfeeding. It is not known whether flibanserin is present in human milk.

What else should I know about flibanserin?

What preparations of flibanserin are available?

Tablets: 100 mg

How should I keep flibanserin stored?

Flibanserin should be stored at room temperature between 15 C and
30 C (59 F and 86 F).

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