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Entresto (sacubitril/valsartan): Side Effects, Uses & Dosage

What are the uses for sacubitril and valsartan?

  • Entresto is used for reducing the risk of
    death and hospitalization for heart failure in patients with chronic heart
    failure (NYHA Class II-IV).
  • Entresto is combined with other heart failure medications
    and in place of an ACE inhibitor or other ARBs.

What brand names are available for sacubitril and valsartan?


Is sacubitril and valsartan available as a generic drug?


Do I need a prescription for sacubitril and valsartan?


What are the side effects of sacubitril and valsartan?

The most common side effects of Entresto are:

Possible serious side effects include:

What is the dosage for sacubitril and valsartan?

  • The initial dose is 49/51 mg twice daily.
  • The dose should be doubled
    after 2 to 4 weeks to the recommended maintenance dose of 97/103 mg twice daily.

Which drugs or supplements interact with sacubitril and valsartan?


  • Combining Entresto with
    ACE inhibitors increases the risk
    of angioedema and other side effects. Combining aliskiren (Tekturna) with
    Entresto increases the risk of kidney failure,
    high blood potassium, and low
    blood pressure. Aliskiren should not be combined with Entresto.
  • Combining Entresto with potassium-sparing diuretics (for example,
    amiloride), potassium
    supplements, or salt
    substitutes containing potassium may lead to increases in serum potassium.
  • Increases in blood
    lithium (Eskalith,
    Lithobid) levels and lithium toxicity have occurred when
    lithium and
    ARBs were combined. Blood lithium levels should be monitored if
    lithium is combined with Entresto.
  • Combining Entresto with

    nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly,
    fluid-depleted (including those on diuretic therapy), or with poor kidney
    function may result in reduced kidney function, including
    kidney failure.

What else should I know about sacubitril and valsartan?

What preparations of sacubitril and valsartan are available?

Tablets: 24/26 mg, 49/51 mg. 97/103 mg (sacubitril/valsartan)

How should I keep sacubitril and valsartan stored?

Entresto should be stored at room temperature, between 15 C and 30 C
(59 F and 86 F).

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