What is metaxalone, and how does it work (mechanism of action)?
Metaxalone is an oral drug that relaxes
skeletal muscle the muscles that control movement of the body. It does not act
directly on skeletal muscle, and the exact mechanism of action of metaxalone is
unknown. Metaxalone relaxes muscles possibly by affecting the central nervous
system (brain and spinal cord) and by causing sedation. Metaxalone was approved
by the FDA in 1962.
What brand names are available for metaxalone?
Skelaxin
Do I need a prescription for metaxalone?
Yes
What are the side effects of metaxalone?
The most common side effects with metaxalone are:
- drowsiness,
- dizziness,
- headache,
- nervousness,
- irritability,
- nausea,
- vomiting,
- and upset stomach.
Other important, but less common, side effects include:
GENERIC AVAILABLE: Yes
What is the dosage for metaxalone?
Metaxalone usually is taken at a dose of 800 mg, three or four
times daily. Benefits are seen within one hour of ingestion. Food high in fat
content increases the absorption of metaxalone.
Which drugs or supplements interact with metaxalone?
No important drug interactions have been described
with metaxalone. Metaxalone may increase the sedative effects of alcohol and
drugs that cause sedation, for example, benzodiazepines (Valium),
antidepressants, opioids (morphine).
Is metaxalone safe to take if I’m pregnant or breastfeeding?
Metaxalone has not been adequately studied in pregnant
women.
NURSING MOTHERS: It is not known whether metaxalone is excreted in
breast milk. Safety for use in the nursing mother has not been established.
What else should I know about metaxalone?
What preparations of metaxalone are available?
Tablets: 800 mg. STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F).