What are the uses for mirabegron?
Mirabegron is a prescription medicine used to treat overactive bladder with symptoms of urgency (a strong need to urinate that is difficult to control), frequency (urinating often), and leakage (accidental urination due to a sudden or uncontrollable urge) in adults.
What brand names are available for mirabegron?
Myrbetriq
Is mirabegron available as a generic drug?
No
Do I need a prescription for mirabegron?
Yes
What are the side effects of mirabegron?
The most common side effects of mirabegron are:
-
Headache - Increased blood pressure
- Constipation
- Dizziness
- Diarrhea
- Back pain
- Dry mouth
- Joint pressure
-
Common cold symptoms
Less commonly, some patients have experienced problems with emptying their
bladder while taking mirabegron.
Possible serious side effects include:
- Heart problems
- Eye problems
- Stevens-Johnson syndrome
- Vaginal infections
- Cancer
-
Urinary tract infection
What is the dosage for mirabegron?
- The recommended starting dose of mirabegron is 25 mg by mouth once
daily. Mirabegron may be taken with or without food. If needed, the dose may be
increased to 50 mg once daily based on individual patient response and
tolerability. - Mirabegron pills are designed to release active medication slowly over
several hours. Mirabegron helps patients manage their symptoms throughout the
day and until the next dose. Therefore, it’s extremely important that patients
do not crush or chew the tablets. - Patients with severe kidney disease (creatinine clearance =30 ml/min) or
patients with moderate liver disease (Child-Pugh Class B) should not take more
than 25 mg of mirabegron per day. - Use of mirabegron is not recommended in patients with end stage renal disease
or in patients with severe
liver disease (Child-Pugh Class C).
Which drugs or supplements interact with mirabegron?
:
- Mirabegron is a moderate inhibitor of CYP2D6
liver enzymes. Taking mirabegron
with medications that are metabolized or broken down by the CYP2D6 enzymes can
result in an increase in their blood levels. - Taking mirabegron with
digoxin causes an increase in digoxin (Lanoxin) blood
levels. Patients taking both medications should use the lowest possible dose of
digoxin to decrease their risk of experiencing side effects. - In clinical studies when mirabegron was administered with
warfarin (Coumadin)
blood levels of warfarin were increased. No effect on International Normalized
Ratio (INR) and prothrombin time was observed. The true significance of this
interaction is yet to be established.
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Is mirabegron safe to take if I’m pregnant or breastfeeding?
:
- Use of mirabegron during
pregnancy has not been adequately
evaluated. Due to the lack of conclusive safety data, mirabegron should be used
in pregnancy only if the potential benefit justifies the potential risk to the
fetus. Mirabegron is classified as FDA pregnancy risk category C. - Although mirabegron was found in the milk of rats in animal
studies, it is not known if mirabegron is excreted in human milk. As many
drugs
are excreted into human milk and have the potential of causing harm to the
nursing infant, mirabegron should only be used during nursing if it is clearly
needed.
What else should I know about mirabegron?
What preparations of mirabegron are available?
Oral extended release tablets: 25 mg and 50 mg
How should I keep mirabegron stored?
Tablets should be stored at room temperature between 15 C to 30 C
(59 F to 86 F).