What is mannitol, and how does it work (mechanism of action)? Mannitol is a naturally occurring substance that causes the body to lose water (diuresis) through osmosis. Mannitol promotes diuresis in kidneys by increasing the concentration of filtrates in the kidney and blocking reabsorption of water by kidney tubules. The FDA approved mannitol in June 1964. What brand names are...
Propafenone (Rythmol) Uses, Side Effects & Dosage
What are the uses for propafenone? Propafenone is an anti-arrhythmic agent approved for use in patients with life-threatening ventricular arrhythmias, such as ventricular tachycardia. Propafenone is also effective in suppressing the recurrence of atrial fibrillation and supra-ventricular tachycardia once normal sinus rhythm has been restored. Propafenone is at least as effective as any other type I agent in converting atrial...
Meropenem (Merrem) Use, Side Effects & Interactions
What is meropenem injection, and how does it work (mechanism of action)? Meropenem is an injectable carbapenem antibiotic. It is similar to impenem and cilastin (Primaxin). Meropenem prevents bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without...
Octreotide (Sandostatin) Uses, Side Effects & Dosage
What is octreotide injection, and how does it work (mechanism of action)? Octreotide acetate is an injectable medicine that is very similar to the hormone somatostatin, which is naturally produced in the body that has several effects including inhibition of the release of hormones. Octreotide works in a similar fashion as somatostatin, but is degraded more slowly and is a...
triamcinolone acetonide nasal (Nasacort) Use, Side Effects & Dosage
What is triamcinolone acetonide nasal inhaler-spray, and how does it work (mechanism of action)? Triamcinolone acetonide is a synthetic (man-made) corticosteroid. It is administered either as an oral metered-dose inhaler for the treatment of asthma (Azmacort), as a topical preparation for the skin (Kenalog; Aristocort) or as a nasal spray (Nasacort AQ) for relieving symptoms of rhinitis. Corticosteroids are naturally...
vardenafil (Levitra, Staxyn ODT) Uses, Side Effects & Dosage
What is vardenafil, and how does it work (mechanism of action)? Vardenafil is an oral drug that is used to treat impotence, the inability to attain or maintain a penile erection. It has a mechanism of action that is similar to sildenafil (Viagra), and tadalafil (Cialis). Penile erection is caused by the engorgement of the penis with blood. This engorgement...
bupivacaine (Marcaine, Sensorcaine) Side Effects & Dosage
What is bupivicaine injection, and how does it work (mechanism of action)? Bupivacaine is a local anesthetic that is similar to lidocaine and mepivacaine (amide type). Bupivacaine, like other local anesthetics reduces the flow of sodium in and out of nerves. This decreases the initiation and transfer of nerve signals in the area in which the drug is applied. This...
Sulindac (Clinoril) Uses, Side Effects & Dosage
What is sulindac, and how does it work (mechanism of action)? Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) that is used for treating pain, fever, and inflammation. Other NSAIDs include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) as well as others. They work by reducing the levels of prostaglandins, chemicals that are produced by the body and are responsible for pain,...
budesonide (Entocort EC, Uceris) for IBD: Side Effects & Dosage
What is budesonide (Entocort EC, Uceris)? Budesonide is a synthetic (man-made) steroid of the glucocorticoid family that is used for treating Crohn’s disease. What brand names are available for budesonide? Entocort EC and Uceris are brand names for budesonide in the US. Why is budesonide (Entocort EC, Uceris) prescribed to patients? Budesonide is used for the treatment of mild-to-moderately-active Crohn’s...
Dexamethasone Injection (Baycadron, Dexamethasone Intensol)
What is dexamethasone, and how does it work (mechanism of action)? Dexamethasone is a synthetic (created by a chemical processes) corticosteroid hormone like prednisone, betamethasone, and triamcinolone. More specifically, dexamethasone is a glucocorticoid hormone, which means that it has anti-inflammatory effects, as well as the ability to affect blood glucose use, fat breakdown, and bone development depending on where it...