Lovenox (enoxaparin) for DVT Side Effects, Pregnancy, Injection

What brand names are available for enoxaparin?

Lovenox

Is enoxaparin available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for enoxaparin?

Yes

What are the uses for enoxaparin?

• Lovenox is used for preventing deep vein thrombosis
  after abdominal surgery, or hip or
  knee replacement surgeries, and in patients
  with reduced mobility due to illness.
• It is used both in and out of the hospital
  for treating deep vein thrombosis and pulmonary embolism.
• Lovenox also is
  used for preventing a second
  heart attack and related complications after a
  heart attack and for preventing blood clots in arterial
  stents.

What are the side effects of enoxaparin?

Common side effect associated with Lovenox are:

• Bleeding
• Fever

• Nausea

• Diarrhea

• Fluid retention

Other possible side effects include:

• Abnormal
  liver tests in the blood
• Mild local irritation
• pain
• Local injection site reaction

Possible serious side
effects include:

• Liver damage
• A reduction in blood platelets
• Red
  blood cells (anemia)
• Major bleeding
• Hematoma

• Ecchymosis

• Erythema

• Atrial fibrillation
• Heart failure
• Pulmonary edema
• Hypersensitivity reactions
• Pneumonia
• Osteoporosis
• Skin necrosis
• Increased potassium
  levels
• Anemia
• Prosthetic heart valve thrombosis

Deep vein thrombosis (DVT) occurs in the _______________.
See Answer

What is the dosage for enoxaparin?

Lovenox is administered by injection under the skin
(subcutaneous) or intravenously.

• Preventing deep vein thrombosis after abdominal surgery: 40 mg
  subcutaneous injection once daily.
• Preventing deep vein thrombosis after knee replacement: 30 mg
  subcutaneous injection every 12 hours.
• Preventing deep vein thrombosis after hip replacement: 30 mg every 12
  hours or 40 mg once daily by subcutaneous injection.
• Preventing deep vein thrombosis in ill patients with limited mobility:
  40 mg subcutaneous injection once daily.
• Treatment of deep vein thrombosis or pulmonary embolism: 1 mg/kg every
  12 hours or 1.5 mg/kg once daily by subcutaneous injection.
• Outpatient treatment of deep vein thrombosis: 1 mg/kg subcutaneous
  injection every 12 hours.
• Treatment of severe heart attacks (ST elevation myocardial infarction or
  STEMI): For patients under the age of 75, 30 mg intravenously plus 1 mg/kg
  subcutaneously followed by 1 mg/kg every 12 hours (maximum of 100 mg for
  each of the first two subcutaneous doses only). For patients over age 75,
  0.75 mg/kg subcutaneously every 12 hours (maximum of 75 mg for each of the
  first two subcutaneous doses only). All patients should receive aspirin.
  Doses should be reduced in patients with impaired kidney function.
• Treatment of chest pain (unstable angina) or mild heart attack
  (non-Q-wave myocardial infarction): 1 mg/kg subcutaneously every 12 hours
  with aspirin.
• For coronary artery stent procedures (percutaneous coronary intervention
  or PCI): Patients should receive 0.3 mg/kg during stent placement if the
  last dose of Lovenox was administered more than 8 hours before the
  procedure.

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Which drugs or supplements interact with enoxaparin?

• Medications that increase the risk of bleeding will
  add to the effects of Lovenox and further increase the risk of bleeding that
  is associated with Lovenox. Such medications include aspirin, clopidogrel (Plavix),
  warfarin (Coumadin), other anticoagulants, and
  nonsteroidal anti-inflammatory
  drugs such as
  ibuprofen (Motrin;
  Advil),
  naproxen (Naprosyn),
  diclofenac (Voltaren),
  and others.

Is enoxaparin safe to take if I’m pregnant or breastfeeding?

• Lovenox does not cross the placenta and shows no
  evidence of effects on the fetus. It often is used during
  pregnancy as an
  alternative to oral anticoagulants such as warfarin (Coumadin), which cannot be
  safely used during pregnancy.
• Lovenox multiple-dose vials contain benzyl
  alcohol as a preservative. Benzyl alcohol has been associated with a fatal “gasping syndrome” in premature neonates.
  Lovenox vials preserved with benzyl alcohol should be used with caution in
  pregnant women and only if clearly needed because benzyl alcohol may cross the placenta.
• It is not known if Lovenox is excreted in breast
  milk. Since most medicines are excreted in breast milk, it is recommended that
  women receiving Lovenox should not
  breastfeed.

What else should I know about enoxaparin?

What preparations of enoxaparin are available?

• Lovenox is available in pre-filled syringes
  containing 30, 40, 60, 80, 100, 120, and 150 mg.
• Multiple dose vial: 300 mg

How should I keep enoxaparin stored?

All Lovenox products should be stored at room temperature, between
15 and 30 C (59 and 86 F).