What is Mytesi, and how does it work?
Mytesi (crofelemer delayed-release tablets) is an anti-diarrheal indicated for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy.
What are the side effects of Mytesi?
Common side effects of Mytesi include:
- upper respiratory tract infection,
- bronchitis,
- cough,
- gas,
- increased bilirubin,
- nausea,
- back pain,
- joint pain,
- urinary tract infection (UTI),
- runny or stuffy nose,
- musculoskeletal pain,
- hemorrhoids,
- giardiasis,
- anxiety,
- increased alanine aminotransferase, and
- abdominal bloating.
What is the dosage for Mytesi?
- Before starting Mytesi, rule out infectious etiologies of diarrhea.
- The recommended adult dosage of Mytesi is 125 mg taken orally two times a day, with or without food.
- Do not crush or chew Mytesi tablets.
- Swallow whole.
What drugs interact with Mytesi?
Nelfinavir, Zidovudine, And Lamivudine
- Mytesi administration did not have a clinically relevant interaction with nelfinavir, zidovudine, or lamivudine in a drug-drug interaction trial.
Is Mytesi safe to use while pregnant or breastfeeding?
- There are no adequate, well-controlled studies in pregnant women.
- This drug should be used during pregnancy only if clearly needed.
- It is not known whether crofelemer is excreted in human milk.
- Because many drugs are excreted in human milk and because of the potential for adverse reactions in nursing infants from
Mytesi, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.